Rajeshkumar et al. World Journal of Pharmacy and Pharmaceutical Sciences. ANTICANCER ACTIVITY OF ANDROGRAPHIS PANICULATA. showing anticancer activity on HEp2 – Human larynx carcinoma cell lines in-vitro KEYWORDS: Andrographis paniculata,Herbal medicine. A refined extract of A. paniculata, also significantly reduces activities of lipid .. The anticancer activity was observed due to the presence of andrographolide.

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Among cancer especially prostrate cancer has been responsible for drastic mortality rate in males. As a matter of fact, a part of this enhancement could be due to an obvious reduction of the plant biomass. Mostly drugs are used to restore the function anrdographis tumor supressor genes.

From natural products to drug discovery. Therefore, in the present study, an attempt was made to wctivity the anticancer potential of hydroalcoholic extracts of A. So, here we are using the natural drugs from phytochemicals to reduce the toxicity level.

The comparison of decrease in studied anticancwr traits in tolerant and sensitive accessions of A. These medicinal plant s possess good immunomodulatory and antioxidant properties, leading to anticancer activities. Prevention of common colds with Andrographis paniculata dried extract: The Graphpad Prism software version 5 was used for drawing the graphs.

The correlative aspects of the three anticancer phytochemicals production as well as the accumulation of proline in the tolerant and sensitive A. The dry weight was used to monitor the physiological response of each accession to salinity.

The materials were soaked for three days at room temperature.


The plant extracts showed potent hepatoprotective Trivedi and Rawal,vermicidal Singh et al. Plant species react against the andrograpjis changes by producing some secondary metabolites such as soluble flavonoids, which protect the cellular structures from oxidative damage and osmotic stress [ 12 ]. The authenticated plants materials were collected from Natural Remedies Pvt.

To receive news and publication updates for BioMed Research International, enter your email address in the box below. However, the standard curves were compared for each sample and the reliability of the peaks was confirmed accordingly. Enhancement of phenolic and flavonoid compounds in onion plant under salinity stress has been reported to improve the deleterious effect of salinity stress [ 34 andrographos.

Reportedly, improving the content of some phytochemicals such as flavonoids as one of the most important pharmaceutical contents could be enhanced through salinity and drought stresses [ 121415 ]. Salinity is a major abiotic stress that causes important alterations in the plant growth and development. All chemicals used were of analytical pniculata.

Analysis of the Anticancer Phytochemicals in Andrographis paniculata Nees. under Salinity Stress

How to cite this article: Recent studies have reported antitumor effects of the flavonoids, quercetin, genistein and baicalein obtained from plant extracts Shoeb et al.

Vertical bars represent standard error of mean for three samples. Consequently, the results suggested that increasing the biosynthesis of proline in the plant could protect the cellular structures from oxidative damage and osmotic stress.

List of the 4 accessions of Andrographis paniculata collected from Peninsular Malaysia. Andrrographis chemical analysis of hydroalcoholic extract of A.

The concentration of the AG, the most important cytotoxic principle in A. However, the production of the three phytochemicals in A. Variance analysis of salinity effects on morphological traits, proline, and the three main phytochemicals in A. It may lead to the accumulation or reduction of certain metabolites [ 1 — 3 ]. Interestingly, the correlation between proline as well as NAG with the other measured morphological characteristics was significant and positive in the salt-stressed plants.


Therefore, the stress conditions have a strong impact on the responsible metabolic pathways for the accumulation actviity the related natural products [ 11 ].

The analysis of variance showed that different levels of salinity affected the proline and the three main phytochemicals of A. Vertical bars represent standard error of mean for each phytochemical.

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In other words, under salinity stress, the tolerant accessions were capable of accumulating the higher amounts of proline, AG, and NAG than the sensitive accessions. The plants grown under salinity conditions performed different responses after four weeks of salt treatment.

Variations due to salinity levels SL and accessions AC were highly significant. Medicinal plants maintain the health and vitality of individuals and cure various diseases, including cancer without causing toxicity. In other words, the increase of these phytochemicals under salinity condition would be partially compensated by a decline in total biomass.

So now a days they are widely used for curing many diseases adnrographis cancer. A pilot double blind study.