Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.

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In this type of system, the reservoir device is coated with a soluble or erodible layer, which dissolves with time and releases the drug after a specified lag period, as in case of a chronotropic system, where the drug is entrapped in the core layer with hydroxyl propyl methyl cellulose Difducaps and with an additional layer of enteric-coated film outside it.

Magnetic carriers receive a response to a magnetic field from incorporated materials, such as magnetite, iron, nickel, cobalt, etc.

Diffucaps Customized Release Technology from Adare Pharmaceuticals

After disengaging, the open mouth of the drug vessel is exposed to the fluid environment. Some of them are enlisted as below:. Introduction Oral drug delivery is the largest segment of the total drug delivery market. Vinupama S, Shwetha S.

Recent technologies in pulsatile drug delivery systems

A new concept of chronopharmaceutics gechnology emerged, wherein research is devoted to tecchnology design and evaluate the drug delivery systems that release a therapeutic agent at a rhythm that ideally matches the biological requirement of a given disease therapy2. It is reported that the weak and non-flexible ethyl cellulose film ruptured adequately as compared with more flexible films. These systems release therapeutic agents in the presence of any biological factor, like enzyme, pH or any other chemical stimuli.


Intestinal protective drug absorption system.

Precipitation of attacks during night or at early morning. International Journal of Pharmacy and Pharmaceutical Sciences techjology 3 2: Recent trends include Multiparticulate drug delivery systems that are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time.

9. Pulsatile Drug Delivery System: Method and Technology Review

The push layer contains among other things, an osmotic agent and water swellable polymers. Electrically actuatable smart nanoporous membrane for pulsatile drug release.

These systems are designed according to the circadian rhythm of the diffucaaps, and the drug is released rapidly and completely as a pulse after a lag time. These systems are considered excellent delivery candidates, since they can be modified according to the task to be achieved.

Diseases requiring pulsatile drug delivery Circadian rhythm regulates many body functions in humans, viz. Recent advances in oral pulsatile drug delivery. Conclusion Rapid advancement and newer developments in the field of drug delivery have led to the formulation of the pulsatile drug delivery system, which, on one hand, can be formulated with ease and, on the other hand, provides a significant amount of therapeutic benefits.

9. Pulsatile Drug Delivery System: Method and Technology Review | Insight Medical Publishing

Formulation and evaluation of floating pulsatile Multiparticulate using pH dependent swellable polymers. As degradation of biodegradable matrix was enhanced by ultrasonic exposure, the rate of drug release also increased.

This swelling of the polymer induced by this pH change which results in insulin release. These systems are beneficial for drugs with chronopharmacological behavior, where nocturnal dosing is required, and for drugs that show the first-pass effect.


For example, 3DP technology is flexible in that it can be used in applications linked to linear drug delivery systems, colon-targeted delivery systems, oral fast disintegrating delivery systems, floating delivery systems, time-controlled and pulse release delivery systems as well as dosage forms with multiphase release properties and implantable DDS.

The two compartments separate from each other by sliding apart.

This device consists of a non-disintegrating half capsule body sealed at the open end with a hydrogel plug that is covered by a water-soluble cap.

European Journal of Pharmaceutical Sciences ; Magnetically triggered nanocomposite membranes: Many weakly basic drugs exhibit pH-dependent solubility profiles. These contained drug concentration gradients designed to complement the volumetric non-uniformity of eroding shells. At this point, degradation products become small enough to be solubilized, and the structure starts to become significantly more porous and hydrated.

Three-dimensional printing 3DP is a novel solid freeform fabrication technology that has been applied to the fabrication of complex pharmaceutical drug devices, or three-dimensional printing 3DP is a rapid prototyping RP technology.

Thermo responsive polymeric micelle systems: Migration inhibiting additives were effective in limiting transport.

Limitations of the technology as relating to pharmaceuticals have been addressed, and prototype dosage forms have been fabricated.